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This compound has long been extensively examined in numerous preclinical styles, showcasing its potential across several domains:

This distinctive binding manner underpins its functional selectivity, as interactions with TM6/7 are vital for β-arrestin activation .

This compound is a style drug and is not prohibited in many nations of the globe as a way for scientific research in Exclusive laboratories.

This material continues to be analyzed on mice and its toxicological and pharmacological knowledge are incomplete.

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Respiratory Depression : this compound manufactured drastically much less respiratory suppression as compared to classic opioids, addressing An important security worry in opioid therapy

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Among the most noteworthy components of this compound's Organic exercise is its atypical phosphorylation profile at the mu-opioid receptor. Initial reports indicated that this compound induces a singular phosphorylation pattern, originally limited to Ser375 inside the very first 20 minutes of exposure. Extended exposure results in multisite phosphorylation akin to large-efficacy agonists like DAMGO

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Substitution: Nucleophilic substitution reactions is often performed making use of reagents like sodium methoxide or potassium tert-butoxide.

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